Chamomile
Monograph · CChamomile (Matricaria chamomilla)
Apigenin-rich herbal tea. Binds benzodiazepine sites on GABA-A receptors at low affinity — mild anxiolytic without strong sedation at typical tea doses.
How it clearsHalf cleared in ~4h. Most (~96%) gone by ~20h.
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Traditional use spans sleep and GI calm. RCTs on chamomile extract (220–1100 mg) show modest improvements in sleep quality and GAD symptoms vs placebo in some trials; effect sizes are small and not universal. Stack catalogs for sleep-outcome logging — not as a sleep prescription.
Early evidence looks promising for tissue-level signaling — but response in this tier splits more than users expect. The same compound at the same dose produces meaningful change in some and near-nothing in others at 4 weeks. That variance is individual biology the data hasn't mapped yet — tracking matters more here than any other tier.
Allergic cross-reactivity with ragweed/aster family possible. Warfarin interaction reported at high extract doses — monitor INR if anticoagulated.
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- CLimited evidence
Chamomile (Matricaria chamomilla) — primary mechanism: apigenin-rich herbal tea. binds benzodiazepine sites on gaba-a receptors at low affinity — mild anxiolytic without strong sedation at typical tea doses.
1 supporting referencesVerified 50d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
GRAS as food/tea. Dietary supplement under DSHEA when sold as extract.
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