EGF (Epidermal Growth Factor)
53-aa polypeptide binding EGFR → MAPK signaling → keratinocyte + fibroblast proliferation + wound-healing acceleration. Topical formulations dominate the cosmetic-dermatology market; injectable use exists in regenerative medicine.
How it clearsHalf cleared in ~1h. Most (~96%) gone by ~5h.
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Cohen + Levi-Montalcini Nobel 1986 work. FDA approval exists for the recombinant version (rhEGF) in diabetic foot ulcers (Regen-D, KGF/Easyef). Cosmetic-dermatology trial body covers wound healing + post-procedure (post-laser, post-microneedling) acceleration. Bryan Johnson's Blueprint Serum lists EGF as one of 8 biomimetic peptides in the formulation. Topical formulations vary widely in actual EGF content + delivery efficacy.
Topical EGF content varies hugely between products — cosmetic formulations often contain trace levels that may not reach functional skin layers. Injectable use for cosmetic indications is off-label + lacks RCT validation. Theoretical concern for accelerating subclinical malignancy via EGFR pathway upregulation — avoid in patients with skin-cancer history.
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EGF (Epidermal Growth Factor) — primary mechanism: 53-aa polypeptide binding egfr → mapk signaling → keratinocyte + fibroblast proliferation + wound-healing acceleration. topical formulations dominate the cosmetic-dermatology market; injectable use exists in regenerative medicine.
2 supporting referencesVerified 13d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
FDA approved (rhEGF for diabetic ulcer) · cosmetic-tier topical formulations legal · injectable cosmetic use is grey
Pre-filled with this compound's published dose range: Topical: 5-50 ppm in serum · twice daily, topical
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