Fadogia Agrestis
West African shrub extract. Proposed LH-mimetic mechanism increasing testicular testosterone production via luteinizing hormone pathway sensitization — though human trial data is sparse.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Popularized by Andrew Huberman. Primary human evidence is essentially nil — testosterone-boosting claims rest on a 2005 rat study (Yakubu et al.) using doses scaling to ~1,200 mg/day in humans. The same rat studies showed dose-dependent testicular toxicity at higher doses, suggesting a narrow therapeutic index in rodents. Until well-powered human RCTs exist, Stack grades testosterone-boosting claims as experimental and the testicular toxicity signal as a real concern at high doses.
Testicular toxicity signal in rat studies at high doses — do NOT exceed established community doses. Monitor labs (testosterone, LH, FSH) if running >8 weeks. Human efficacy data is essentially absent — you are extrapolating from rodents.
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Not FDA-reviewed for efficacy. Sold as dietary supplement under DSHEA. No prohibited status under WADA.
Distilled themes from named communities — Reddit threads, forums, creator commentary. Not direct quotes; not clinical evidence. Useful for calibrating expectations against what real self-experimenters report.
High adoption post-Huberman podcast mention. Community reports subjective libido/energy improvement at 400 mg. No controlled comparison data to separate placebo. Cycling 8 weeks on / 4 weeks off is the common harm-reduction protocol.