Fadogia
Monograph · DFadogia Agrestis
West African shrub extract. Proposed LH-mimetic mechanism increasing testicular testosterone production via luteinizing hormone pathway sensitization — though human trial data is sparse.
How it clearsHalf cleared in ~6h. Most (~96%) gone by ~1d.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Popularized by Andrew Huberman. Primary human evidence is essentially nil — testosterone-boosting claims rest on a 2005 rat study (Yakubu et al.) using doses scaling to ~1,200 mg/day in humans. The same rat studies showed dose-dependent testicular toxicity at higher doses, suggesting a narrow therapeutic index in rodents. Until well-powered human RCTs exist, Stack grades testosterone-boosting claims as experimental and the testicular toxicity signal as a real concern at high doses.
Limited human data. The mechanism touches a sensitive regulatory axis, which means effects — when they appear — tend to be more pronounced than in other categories. Both undershoot and overshoot are real outcomes here. This is the tier where tracking matters most and flying blind costs most.
Testicular toxicity signal in rat studies at high doses — do NOT exceed established community doses. Monitor labs (testosterone, LH, FSH) if running >8 weeks. Human efficacy data is essentially absent — you are extrapolating from rodents.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- DMechanistic / anecdotal
West African shrub extract
1 supporting referencesVerified 24d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Not FDA-reviewed for efficacy. Sold as dietary supplement under DSHEA. No prohibited status under WADA.
Distilled themes from named communities — Reddit threads, forums, creator commentary. Not direct quotes; not clinical evidence. Useful for calibrating expectations against what real self-experimenters report.
High adoption post-Huberman podcast mention. Community reports subjective libido/energy improvement at 400 mg. No controlled comparison data to separate placebo. Cycling 8 weeks on / 4 weeks off is the common harm-reduction protocol.
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Handoff & sources
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