Fisetin
Flavonoid polyphenol found in strawberries and other fruits. Senolytic activity: selectively induces apoptosis in senescent cells. Also activates SIRT1 and inhibits mTORC1, contributing to autophagy induction.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Ranked highest senolytic in a Mayo Clinic screening of 46 compounds (Kirkland 2017). In vivo mouse data shows improved late-life healthspan and some lifespan extension. Human data limited to a small pilot RCT in Alzheimer's (NCT03593265) and a COSMOS-Mind cognitive substudy. Bioavailability is poor in standard form — lipid-formulated (CognitiQ®, Senolytic brand) improves absorption ~25×. Pulse dosing (2–3 consecutive days/month at 500 mg–1 g) mirrors the mouse protocols and is the common human strategy.
Most compelling data is from mice — human translation uncertain. Blood pressure: some case reports of hypotension at high doses. CYP3A4 and CYP2C9 inhibition — check interactions if on warfarin, statins, or other CYP substrates.
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Dietary supplement (DSHEA). No FDA drug approval. ClinicalTrials.gov: active longevity trials.
Distilled themes from named communities — Reddit threads, forums, creator commentary. Not direct quotes; not clinical evidence. Useful for calibrating expectations against what real self-experimenters report.
Stacked with Dasatinib+Quercetin for senolytic protocols — though the D+Q combination has a stronger RCT base. Fisetin preferred by users wanting an OTC senolytic without a prescription drug.