FOXO4-DRI
Monograph · DFOXO4-DRI
D-retro-inverso peptide. Disrupts FOXO4-p53 interaction in senescent cells, triggering selective apoptosis (senolytic mechanism).
How it clearsHalf cleared in ~30min. Most (~96%) gone by ~2.5h.
Compare these compounds
Mechanism, evidence, legal path, cost — all side-by-side.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Erasmus MC (Baar et al. 2017) showed targeted clearance of senescent cells in aged mice with reduced frailty markers. No human trials. Often cited as the prototype peptide senolytic — but the Erasmus group has not advanced human studies as of 2025.
Early-stage — most claims are extrapolated from animal or in-vitro studies with no human replication at scale. Longevity effects specifically resist short-term human measurement, which means both positive and negative signals are genuinely difficult to read.
Pure research compound. No human safety data. Self-administering a senolytic without medical oversight carries unknown systemic risks. Most products sold as 'FOXO4-DRI' to consumers are unverifiable in identity.
Upload your data to see how it relates to FOXO4-DRI.
Upload a lab file (LabCorp / Quest) or DNA file (23andMe / AncestryDNA). Stack will show your specific markers alongside the literature-reported response windows.
Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- DMechanistic / anecdotal
FOXO4-DRI targets senescent cell clearance in mouse models
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: varies — research only · research-only protocols
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
No field reports yet
Field reports are added as users share their real-world protocols.
Next visit & citations
Handoff & sources
Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.