Glutathione (IV / oral / liposomal)
Endogenous tripeptide antioxidant (Gly-Cys-Glu). Master cellular antioxidant — neutralizes ROS, supports Phase II liver detoxification, recycles vitamin C + E. IV infusion or liposomal-encapsulated oral forms bypass GI degradation issues of conventional oral glutathione.
How it clearsHalf cleared in ~12min. Most (~96%) gone by ~1h.
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Most-studied therapeutic indication is Parkinson's disease (Sechi 1996, Hauser 2009 — modest functional improvement). Off-label longevity-clinic use targets: subjective energy/fatigue, skin lightening (East Asian + Southeast Asian cohort heavy use), liver-detox protocols, post-chemotherapy recovery support. IV glutathione raises plasma + RBC levels acutely; sustained intracellular elevation requires precursor strategies (NAC, GlyNAC) more than direct glutathione. The skin-lightening claim is the most-marketed but FDA explicitly warned 2015 against injectable glutathione for cosmetic skin lightening due to severe adverse events.
IV glutathione for cosmetic skin lightening was the subject of an explicit FDA 2015 warning citing severe adverse events including Stevens-Johnson syndrome, toxic epidermal necrolysis, and kidney dysfunction. Stack does NOT recommend the cosmetic-skin-lightening use case. Therapeutic-tier IV use for fatigue / liver-detox protocols carries 503A compounding-quality risk. Oral glutathione has poor bioavailability — liposomal or NAC precursor delivery is more pharmacologically defensible.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- CLimited evidence
Improves motor function in Parkinson's disease via IV administration.
1 supporting referencesVerified today - DMechanistic / anecdotal
Lightens skin tone safely when administered intravenously.
1 supporting referencesVerified today
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Oral supplement OTC · IV glutathione is 503A-compounded · FDA 2015 warned against injectable for skin lightening cosmetic use
Pre-filled with this compound's published dose range: IV: 600-2400 mg per infusion · oral liposomal: 250-1000 mg/day · weekly to monthly (IV) · daily (oral)
Draw volume exceeds 100 units (1 mL). Either reduce dose or split into multiple injections.
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
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