Ivermectin
Macrocyclic lactone antiparasitic. Binds glutamate-gated chloride channels in invertebrates; secondary effects on GABA-A and farnesoid X receptors at higher doses.
FDA-approved for onchocerciasis (river blindness), strongyloidiasis, and topical scabies / rosacea (Soolantra). Off-label cohort use spans cancer-adjunct protocols (FLCCC + Joe Tippens lineage), long-COVID stacks, and Lyme co-infection regimens. The off-label claims have been controversial: large RCTs (TOGETHER 2022, ACTIV-6 2022) found no COVID-mortality benefit; small studies suggesting cancer cell-line antiproliferation at doses far above human-tolerable serum levels have not translated to clinical efficacy. Stack catalogs ivermectin for the SAFETY interaction surface — users in r/StackAdvice cancer-adjunct + long-COVID threads stack it with peptides + GLP-1 + supplements regularly, and CYP3A4 + P-glycoprotein interactions are real.
Distilled themes from named communities — Reddit threads, forums, creator commentary. Not direct quotes; not clinical evidence. Useful for calibrating expectations against what real self-experimenters report.
Cohort splits sharply: FLCCC-adjacent users report subjective improvement; mainstream-medicine cohort points to RCT-null results. Stack's posture is to document both honestly + flag the real CYP/warfarin interactions either way.
Stacked with fenbendazole + vitamin E + curcumin. Anecdotal case reports only — no controlled trials of the combination.
REAL DRUG INTERACTIONS: warfarin (potentiation), CYP3A4 inducers (rifampin, phenytoin), strong CYP3A4 inhibitors (ketoconazole, ritonavir — increase serum levels). Off-label COVID + cancer claims are graded D below — large RCTs found no benefit at human-tolerable doses. Veterinary-formulation ivermectin (paste + injectable) is NOT pharmaceutical-grade; FDA + poison-control reports of toxicity from horse-paste self-dosing are real. If you're running ivermectin off-label, do it under a clinician familiar with the literature, not from a Telegram protocol.
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
- RegulatoryENREGULATORYNIH-fundedVerified 3d agoFDA — Ivermectin label (parasitic indications)
- PubMedENRCTAcademic-fundedVerified 3d agoReis G et al. — TOGETHER trial: ivermectin no COVID benefit (NEJM 2022)
- PubMedENRCTNIH-fundedVerified 3d agoNaggie S et al. — ACTIV-6 ivermectin no COVID benefit (JAMA 2022)
- ReferenceENQUESTIONEDANECDOTALSelf-fundedVerified 3d agoFLCCC — I-Recover long-COVID protocol (industry-conflicted)
FLCCC protocols cite ivermectin off-label benefits not supported by large RCTs. Cited here for cohort-presence honesty, not endorsement.
- PubMedENMECHANISTICAcademic-fundedVerified 3d agoPubMed — ivermectin oncology preclinical literature
FDA-approved for onchocerciasis + strongyloidiasis + topical rosacea/scabies. Off-label use is not FDA-endorsed for COVID, cancer, or long-COVID.