Klotho
Monograph · DKlotho (research)
Single-pass transmembrane protein with a soluble form regulating FGF23, IGF-1 signaling, and oxidative stress response. Genetic Klotho overexpression extends lifespan in mice.
How it clearsHalf cleared in ~4h. Most (~96%) gone by ~20h.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Discovered as the gene whose mutation causes premature aging in mice (Kuro-o lab). Klotho variants in humans correlate with longevity and cognitive function. Recombinant or fragment-derived 'Klotho protein' marketed by some grey-market vendors lacks identity verification. True therapeutic Klotho is at the gene-therapy / large-protein-engineering frontier, not the SubQ peptide tier.
Early-stage — most claims are extrapolated from animal or in-vitro studies with no human replication at scale. Longevity effects specifically resist short-term human measurement, which means both positive and negative signals are genuinely difficult to read.
Real therapeutic Klotho doesn't exist as a stable consumer-injectable yet. Anything sold as 'Klotho' to a biohacker should be verified via independent assay; identity claims are weak. KL-VS genotyping is observational, not a treatment trigger.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- DMechanistic / anecdotal
Single-pass transmembrane protein with a soluble form regulating FGF23, IGF-1 signaling, and oxidative stress response
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: research-only · no human dosing established
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