Larazotide
Monograph · CLarazotide
Octapeptide tight-junction regulator. Antagonizes zonulin to restore intestinal epithelial barrier integrity.
How it clearsHalf cleared in ~30min. Most (~96%) gone by ~2.5h.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
9 Meters Biopharma's lead candidate (CEDLARA Phase 3 in celiac). Reduces tight-junction permeability rather than directly modulating immune cells. Phase 3 results were mixed in 2022. Still positioned as an adjunct for refractory celiac and explored for long-COVID gut symptoms.
Early evidence looks promising for tissue-level signaling — but response in this tier splits more than users expect. The same compound at the same dose produces meaningful change in some and near-nothing in others at 4 weeks. That variance is individual biology the data hasn't mapped yet — tracking matters more here than any other tier.
Not approved. Phase 3 results were not unambiguously positive. Self-experimentation outside trial protocols carries unknown long-term risk for chronic GI conditions.
Upload your data to see how it relates to Larazotide.
Upload a lab file (LabCorp / Quest) or DNA file (23andMe / AncestryDNA). Stack will show your specific markers alongside the literature-reported response windows.
Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- CLimited evidence
Larazotide acetate tightens intestinal barrier in celiac mechanistic studies
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 0.5 mg · before meals, oral
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
No field reports yet
Field reports are added as users share their real-world protocols.
Next visit & citations
Handoff & sources
Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.