Lemon balm
Monograph · CLemon balm (Melissa officinalis)
Rosmarinic acid + citral terpenes. Inhibits GABA transaminase, increasing GABA availability — mild calming effect.
How it clearsHalf cleared in ~3h. Most (~96%) gone by ~15h.
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Used in traditional European herbalism for anxiety and sleep. Small RCTs (600 mg standardized extract) report reduced anxiety and improved sleep quality vs placebo in stressed adults. Often combined with valerian or chamomile in cohort practice.
Early evidence looks promising for tissue-level signaling — but response in this tier splits more than users expect. The same compound at the same dose produces meaningful change in some and near-nothing in others at 4 weeks. That variance is individual biology the data hasn't mapped yet — tracking matters more here than any other tier.
Thyroid: high doses may inhibit TSH — relevant for hypothyroid users on levothyroxine. Sedation additive with other GABAergics.
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- CLimited evidence
Lemon balm (Melissa officinalis) — primary mechanism: rosmarinic acid + citral terpenes. inhibits gaba transaminase, increasing gaba availability — mild calming effect.
1 supporting referencesVerified 50d ago
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