Matrixyl 3000 (Palmitoyl Pentapeptide-4)
Synthetic pentapeptide (Pal-KTTKS) developed by Sederma. Mimics a procollagen-I fragment; topically signals fibroblasts to upregulate collagen + glycosaminoglycan synthesis.
How it clearsHalf cleared in ~12h. Most (~96%) gone by ~3d.
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Robinson 2005 RCT (N=93) showed measurable wrinkle-depth reduction over 12 weeks daily application — became the foundational cosmeceutical-peptide trial. Matrixyl 3000 is the blended formula (Pal-KTTKS + Pal-Glycyl-Histidyl-Lysine) that Sederma trademarked; it's now in hundreds of mid-to-premium skincare formulations. Like Argireline, real effect is modest but consistent.
Effect emerges over 8-12 weeks of consistent use — not an overnight intervention. Stratum-corneum penetration depends on formulation quality. Stacking with retinoids amplifies irritation risk in sensitive skin types.
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Matrixyl 3000 (Palmitoyl Pentapeptide-4) — primary mechanism: synthetic pentapeptide (pal-kttks) developed by sederma. mimics a procollagen-i fragment; topically signals fibroblasts to upregulate collagen + glycosaminoglycan synthesis.
1 supporting referencesVerified 13d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Cosmetic-ingredient classification (US/EU/MX) · widely sold OTC across mid-premium skincare
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