NAC (N-Acetyl Cysteine)
Glutathione precursor and cysteine donor. Primary antioxidant replenishment pathway. Also mucolytic and hepatoprotective. Widely used for liver protection, addiction recovery, and OCD adjunct therapy.
NAC restores intracellular glutathione, the body's master antioxidant. FDA-approved as mucolytic and acetaminophen overdose antidote. Meta-analyses show meaningful benefit for COPD, psychiatric disorders (OCD, depression adjunct), and infertility. Longevity use is based on glutathione depletion with aging and mitochondrial oxidative stress theory.
GI upset at high doses — split into 2 doses. Sulfur smell is normal. May blunt some exercise adaptations (antioxidant paradox). Anticoagulant interaction at very high doses. Rare: bronchospasm with inhaled form.
Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- BModerate evidence
NAC (N-Acetyl Cysteine) — primary mechanism: glutathione precursor and cysteine donor. primary antioxidant replenishment pathway. also mucolytic and hepatoprotective. widely used for liver protection, addiction recovery, and ocd adjunct therapy.
2 supporting referencesVerified 5d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
FDA-approved drug (mucolytic/antidote). Also sold as supplement — FDA tried to remove supplement status 2020, backed off.