NAD+ injectable / IV
Direct administration of NAD+ (rather than its precursors NMN or NR). IV infusion or subcutaneous injection bypasses the salvage-pathway conversion needed for oral precursors. The longevity-clinic standard for 'rapid NAD+ pool restoration.'
How it clearsHalf cleared in ~2h. Most (~96%) gone by ~10h.
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Mechanism, evidence, legal path, cost — all side-by-side.
Evidence is experimental. Most claims trace to limited human studies or animal models. Treat as a research direction, not a protocol.
Marek Health, Ways2Well, Cenegenics, and most longevity-clinic chains offer IV NAD+ protocols (typically 250-1000 mg over 2-4 hours, weekly or monthly). The pharmacokinetic question — whether IV NAD+ raises intracellular NAD+ pools meaningfully more than oral precursors — has limited published data. Grant et al 2019 (small N) showed IV NAD+ achievable plasma rise but intracellular conversion remains the bottleneck. Most clinics market this on subjective energy/cognition outcomes, which lack RCT-grade validation.
Pharmacokinetic justification for IV NAD+ over cheaper oral NR/NMN is contested in academic literature. Infusion experience is unpleasant (chest pressure, flushing, headache during drip — slows infusion rate but doesn't eliminate). Cost-per-mg is dramatically higher than oral precursors. 503A compounding pharmacy quality varies — verify PCAB / NABP accreditation.
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- CLimited evidence
Raises plasma NAD+ levels more rapidly than oral NR/NMN.
1 supporting referencesVerified today - DMechanistic / anecdotal
Produces clinically meaningful improvement in subjective energy + cognition in healthy adults.
0 supporting referencesVerified today
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
503A compounded by longevity clinics · no FDA approval · widely offered at $200-$800 per infusion
Pre-filled with this compound's published dose range: 250-1000 mg per infusion · weekly to monthly, IV or SC
Draw volume exceeds 100 units (1 mL). Either reduce dose or split into multiple injections.
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
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