Nicotinamide Riboside (NR / Niagen)
NAD+ precursor — converts to NMN then NAD+ via the salvage pathway. Sister molecule to NMN with similar end-state biology. Chromadex commercialized as Niagen (FDA-GRAS 2016).
How it clearsHalf cleared in ~7h. Most (~96%) gone by ~1d.
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Mechanism, evidence, legal path, cost — all side-by-side.
More published human RCTs than NMN as of 2026 (the NR commercialization predates the NMN wave by ~5 years). Trammell 2016 first-in-human study + multiple follow-ups document dose-dependent NAD+ pool rise. Clinical-outcome benefits remain modest: small signals in blood-pressure (Martens 2018), exercise-recovery (Dolopikou 2020), Parkinson's biomarkers (Brakedal 2022). No large mortality or healthspan RCT. NMN is the more-hyped molecule in 2024-26 but the NR evidence base is actually deeper.
Hype outpaces clinical-outcome evidence. Biomarker shifts (raised NAD+ pool) are real and replicate; mortality + healthspan endpoints have not been studied at scale. ChromaDex vs Elysium NR-vs-Basis patent dispute is a brand-decision noise factor, not a biology factor. Long-term NAD+ pool elevation has theoretical concerns around methylation balance + theoretical cancer-cell metabolism support.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- AStrong evidence
Raises systemic NAD+ pool dose-dependently in humans.
1 supporting referencesVerified today - CLimited evidence
Extends healthspan or reduces age-related disease incidence in humans.
1 supporting referencesVerified today
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
FDA-GRAS supplement (2016) · ChromaDex commercial (Niagen + ingredient supply for ~75 other brands)
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