Noopept
Monograph · CNoopept
Russian-developed dipeptide nootropic. NGF + BDNF upregulator with reported cognitive + neuroprotective effects at sub-milligram doses.
How it clearsHalf cleared in ~24min. Most (~96%) gone by ~2h.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
N-phenylacetyl-L-prolylglycine ethyl ester. Russian Academy of Sciences synthesized in 1996; clinical use approved in Russia 2000. Active dose is ~1000× lower than piracetam (10-30 mg vs 1.6-4.8 g) because it crosses BBB efficiently and metabolizes to cycloprolylglycine (CPG), which mimics endogenous neurotrophin signaling. Small Russian RCTs in mild cognitive impairment + post-traumatic encephalopathy show modest cognitive improvement; Western trial data is sparse.
Promising cognitive signal that holds up in early trials — but cognitive effects resist self-assessment at low deltas. The brain adjusts to its own baseline quickly, meaning real improvements can feel like nothing from the inside. Task performance tracks better than sensation here.
Quality varies wildly by vendor — Russian-source medical-grade vs research-chemistry powder. Third-party HPLC verification is the only honest way to verify a vendor. Tolerance can develop within 8-12 weeks of daily use; community wisdom is to cycle 6 weeks on / 2 weeks off. Mild irritability + sleep disruption reported at high doses.
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- CLimited evidence
Russian-developed dipeptide nootropic
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Not FDA-approved in US — sold as research compound. Prescription medicine in Russia (Noopept brand) and some FSU states.
Distilled themes from named communities — Reddit threads, forums, creator commentary. Not direct quotes; not clinical evidence. Useful for calibrating expectations against what real self-experimenters report.
Cohort consensus: cleaner than racetams + faster onset (often within 30-60 min sublingual). Cycling required to avoid tolerance. Choline pairing optional — less consistently reported as needed than with piracetam.
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