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Monograph
FDA APPROVEDP-036
Hormones

Oxytocin

Nine-amino acid neuropeptide. Endogenous bonding/affiliative signaling; pharmaceutical use in obstetrics and as off-label adjunct in social-anxiety / autism research.

EmergingHormones
Typical dose10-40 IU
Frequencyas-needed, intranasal
Half-life0.05h
Citations indexed245
DeliveryInjectable
Half-life~3min
EvidenceEmerging
Citations245
Synergy checkCompareReconstitution calc
Mechanism

FDA-approved as IV/IM Pitocin for labor induction. Intranasal oxytocin is the form used in psychiatric research; replication of social-cognition effects has been mixed. Compounded sublingual/intranasal forms common in concierge psychiatry.

Specifics
AnxietyMoodLibido / sexual function
Caveats

Intranasal absorption is variable. Behavioral effects in well-controlled trials have been less reliable than early enthusiasm suggested. Cardiovascular effects with high IV doses are real (obstetric context).

sequence · 9 aa
CYIQNCPLG

Cyclic structure: Cys-Cys disulfide bridge between residues 1 and 6. C-terminal amide.

Evidence levelEmerging
Regulatory statusFDA approved (Pitocin) for labor; off-label psychiatric use
DNA / pharmacogenomicsModerate — OXTR rs53576 variant correlates with social-behavior phenotypes; not actionable for dosing.
Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • CLimited evidence

    Oxytocin — primary mechanism: nine-amino acid neuropeptide. endogenous bonding/affiliative signaling; pharmaceutical use in obstetrics and as off-label adjunct in social-anxiety / autism research.

    1 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — Intranasal oxytocin trials
Reconstitution calculatorOxytocin

Pre-filled with this compound's published dose range: 10-40 IU · as-needed, intranasal

Concentration2.50 mg/mL
Draw volume0.100 mL
Insulin syringe10.0 u
Doses per vial20
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

FDA APPROVEDP-036

FDA approved (Pitocin) for labor; off-label psychiatric use

Oxytocin10-40 IU · as-needed, intranasal
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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