PDGF (Platelet-Derived Growth Factor)
Dimeric glycoprotein released by activated platelets. Drives mesenchymal cell proliferation + chemotaxis at injury sites. Core mediator of platelet-rich plasma (PRP) therapeutic effect.
How it clearsHalf cleared in ~2h. Most (~96%) gone by ~10h.
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FDA approval exists for becaplermin (recombinant PDGF-BB, Regranex gel) in diabetic neuropathic ulcers. The major real-world exposure most people have to PDGF is via PRP injections — orthobiologic clinics inject autologous PDGF-rich plasma for tendinopathy, osteoarthritis, hair restoration. Synthetic injectable PDGF outside the PRP context is research-grey. Blueprint Serum includes PDGF as one of 8 biomimetic peptides.
Regranex carries a black-box warning for potential malignancy risk (cancer-mortality signal in patients with prior cancer history). Autologous PRP is generally safer than synthetic recombinant — verify clinic preparation protocol + spin counts. Cosmetic claims for hair restoration via injectable PDGF exceed RCT evidence base.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- CLimited evidence
PDGF (Platelet-Derived Growth Factor) — primary mechanism: dimeric glycoprotein released by activated platelets. drives mesenchymal cell proliferation + chemotaxis at injury sites. core mediator of platelet-rich plasma (prp) therapeutic effect.
2 supporting referencesVerified 13d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
FDA approved (Regranex for diabetic ulcer) · PRP autologous use widely practiced · synthetic injectable cosmetic use is grey
Pre-filled with this compound's published dose range: Topical/injected: protocol-dependent (PRP autologous) · per protocol
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