Rapamycin
Monograph · CRapamycin (Sirolimus)
mTORC1 inhibitor. Suppresses autophagy signaling enough to extend lifespan in multiple animal models. Used off-label for longevity at low intermittent doses (Kaeberlein protocol).
How it clearsHalf cleared in ~3d. Most (~96%) gone by ~13d.
Compare these compounds
Mechanism, evidence, legal path, cost — all side-by-side.
Evidence is experimental. Most claims trace to limited human studies or animal models. Treat as a research direction, not a protocol.
mTOR inhibition extends lifespan in yeast, worms, flies, and mice — even when started in late life. The Kaeberlein protocol (1–6 mg/week intermittently) aims to get autophagy benefits without continuous immunosuppression. No longevity RCTs in humans exist. FDA-approved for transplant rejection (not longevity). Significant side-effect profile at therapeutic doses; low-dose intermittent may be safer but is unstudied.
Early-stage — most claims are extrapolated from animal or in-vitro studies with no human replication at scale. Longevity effects specifically resist short-term human measurement, which means both positive and negative signals are genuinely difficult to read.
Immunosuppressive at therapeutic doses — increased infection risk. Mouth sores (aphthous ulcers), hyperlipidemia, hyperglycemia. Off-label use is unmonitored. Requires a prescribing provider willing to prescribe off-label. Interactions with CYP3A4 inhibitors (grapefruit, ketoconazole) can cause dose stacking.
Upload your data to see how it relates to Rapamycin.
Upload a lab file (LabCorp / Quest) or DNA file (23andMe / AncestryDNA). Stack will show your specific markers alongside the literature-reported response windows.
Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- CLimited evidence
Rapamycin inhibits mTOR — longevity effects studied in animals and small human pilots
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
No field reports yet
Field reports are added as users share their real-world protocols.
Next visit & citations
Handoff & sources
Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.