Sermorelin
Monograph · BSermorelin
29-amino acid GHRH analog. Stimulates pulsatile endogenous growth hormone release; gentler than synthetic GH.
How it clearsHalf cleared in ~12min. Most (~96%) gone by ~1h.
GHRH(1-29). Originally FDA-approved as Geref for pediatric GH deficiency (withdrawn 2008 commercially). Now produced via 503A compounding for adult anti-aging clinics. Triggers physiologic pulsatile GH release rather than the supraphysiologic spike of recombinant HGH.
Documented hormonal pathway with strong mechanistic support. Response is not uniform — users with significant baseline deficiency feel signal earlier and more clearly than those near the normal range. If response feels subtle, that is often a baseline reading, not a compound failure.
Original Geref withdrawn for commercial reasons, not safety. Compounded sermorelin quality varies; verify pharmacy accreditation (PCAB / NABP).
GHRH(1-29).
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- BModerate evidence
Sermorelin stimulates GH release via GHRH receptor agonism
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 200-500 µg · nightly, subcutaneous
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
Public-source attribution across the production + distribution chain. Stack does not endorse vendors — this is who is in the chain, not which one is best.
Empower Pharmacy
USVERIFIEDPCAB ACCREDITEDBPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin · Semaglutide · Tirzepatide
Houston-based 503A compounding pharmacy, one of the largest in the US peptide compounding market.
Source: Empower Pharmacy — peptide compoundingVerified 50d agoTailor Made Compounding
USVERIFIEDPCAB ACCREDITEDBPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin
Source: Tailor Made CompoundingVerified 50d agoOlympia Pharmaceuticals
USVERIFIEDPCAB ACCREDITEDBPC-157 · Sermorelin · CJC-1295/Ipamorelin
Source: Olympia Pharmaceuticals — compounding pharmacyVerified 50d agoStrive Pharmacy
USSELF-REPORTEDPCAB ACCREDITEDSermorelin · Ipamorelin · BPC-157
Source: Strive PharmacyVerified 50d ago
Peptide Partners
Research3rd-party COA per batchFinnrick ✓US · CA · AU · UKOne of the most consistently recommended vendors on r/Peptides since the Peptide Sciences shutdown (March 2026). Third-party COA published per batch. HPLC purity ≥99%.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Paradigm Peptide
Research3rd-party COA per batchFinnrick ✓US · CALong-established US vendor (7+ years). Broad catalog including GHRPs, GHRHs, and cognitive peptides. Third-party HPLC and mass-spec COA per batch. Active Finnrick Analytics coverage.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Orbitrex Peptides
Research3rd-party COA per batchUSNewer vendor with fast turnaround and competitive pricing. Third-party COA on all products. Building Finnrick coverage. Frequently recommended post-Peptide Sciences shutdown.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Polaris Peptides
Research3rd-party COA on requestFinnrick ✓US · CAEstablished vendor with multi-year community track record. Offers peptide blends (Wolverine Stack, etc.) alongside singles. Third-party COA available on request.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
XL Peptides
Research3rd-party COA per batchFinnrick ✓US · CA · AUKnown for above-average catalog depth, including harder-to-find compounds (SS-31, humanin, Foxo4-DRI). Third-party HPLC published. Active Finnrick coverage.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Core Peptides
Research3rd-party COA on requestUSClean storefront, competitive pricing, strong community mentions. Third-party COA on most products. Ships to US with fast turnaround.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Defy Medical
Telehealth3rd-party COA per batchUSTampa-based telehealth clinic specializing in hormone and peptide therapy. Prescribing provider + compounding pharmacy fulfillment. BPC-157, CJC/Ipa, Ipamorelin, PT-141, Sermorelin. Prescription required.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
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Handoff & sources
Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.