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Monograph
RESEARCH GREYP-067
Metabolic

SLU-PP-332

Pan-ERR (estrogen-related receptor) agonist. Drives mitochondrial biogenesis + fatty-acid oxidation in skeletal muscle — preclinical 'exercise mimetic' candidate. Discovered + characterized at Saint Louis University (Burris lab).

ExperimentalMetabolic
Typical doseUnknown in humans (mouse: 10 mg/kg)
Frequencyexperimental — no human protocol
Half-life6h
Citations indexed9
100%50%0%06h12h18h1d1.3dt½ 6hPK · plasma

How it clearsHalf cleared in ~6h. Most (~96%) gone by ~1d.

DeliveryInjectable
Half-life~6h
EvidenceExperimental
Citations9
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Research grey

This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.

Mechanism

Billman + Burris lab (Saint Louis University) published 2023 mouse data showing SLU-PP-332 administration produced exercise-mimetic effects: improved running endurance, mitochondrial biogenesis, fat oxidation — without exercise itself. The compound is a research tool — no human safety data, no clinical trials, no GMP supply chain. Grey-market product appearing in 2024-25 in biohacker forums is unverified material with no quality-control body. Frontier-tier speculative.

Specifics
Mitochondrial energy declineBody composition (lean mass)Weight / fat loss
Caveats

Frontier-tier speculative compound. Zero human safety data. Long-term ERR-agonism has un-modeled cardiac + metabolic concerns (the receptors are central regulators of cardiac energy metabolism). Identity verification of grey-market product is essentially impossible. Stack catalogs this for awareness + harm-reduction context, not endorsement. DIY use is a self-experiment of one with no off-ramp.

Evidence levelExperimental
Regulatory statusResearch tool only · no FDA pathway · grey-market product is unverified material
DNA / pharmacogenomicsLow — ESRRA/B/G polymorphisms theoretically modulate; PG not actionable.
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Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • DMechanistic / anecdotal

    SLU-PP-332 — primary mechanism: pan-err (estrogen-related receptor) agonist. drives mitochondrial biogenesis + fatty-acid oxidation in skeletal muscle — preclinical 'exercise mimetic' candidate. discovered + characterized at saint louis university (burris lab).

    2 supporting referencesVerified 13d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 13d ago
    PubMed — SLU-PP-332 ERR agonist exercise mimetic mouse
  • ReferenceEN
    MECHANISTICFunding undisclosedVerified 13d ago
    Burris lab — Saint Louis University
RESEARCH GREYP-067

Research tool only · no FDA pathway · grey-market product is unverified material

Can I get it? →
Reconstitution calculatorSLU-PP-332

Pre-filled with this compound's published dose range: Unknown in humans (mouse: 10 mg/kg) · experimental — no human protocol

Concentration2.50 mg/mL
Draw volume4.000 mL
Insulin syringe400.0 u
Doses per vial0
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u
Watch

Draw volume exceeds 100 units (1 mL). Either reduce dose or split into multiple injections.

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

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Field reports are added as users share their real-world protocols.

SLU-PP-332Unknown in humans (mouse: 10 mg/kg) · experimental — no human protocol

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