Spermidine
Monograph · DSpermidine
Polyamine found in wheat germ, soybeans, and aged cheese. Induces autophagy independently of mTOR. Shown to extend lifespan in multiple model organisms including mice.
How it clearsHalf cleared in ~12h. Most (~96%) gone by ~3d.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Eisenberg et al. (2009) showed lifespan extension in yeast, flies, and worms — then in mice. The Graz study (Austria, 2018) showed lower risk of cognitive decline with higher dietary spermidine intake in a large cohort. The supplement form (wheat germ extract standardized to spermidine) avoids the high-temperature instability of pure spermidine. Combined with rapamycin or caloric restriction in some longevity protocols.
Early-stage — most claims are extrapolated from animal or in-vitro studies with no human replication at scale. Longevity effects specifically resist short-term human measurement, which means both positive and negative signals are genuinely difficult to read.
Wheat germ extract products have poor standardization — spermidine content varies dramatically. Most human evidence is observational. Supplemental doses are far lower than doses used in animal lifespan studies (relative to body mass).
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- DMechanistic / anecdotal
Polyamine found in wheat germ, soybeans, and aged cheese
1 supporting referencesVerified 23d ago
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