Urolithin A
Monograph · CUrolithin A
Postbiotic produced when gut microbiome metabolizes ellagitannins (from pomegranate, walnuts, berries). Activates mitophagy — the selective clearance of damaged mitochondria. Timeline is weeks, not days.
How it clearsHalf cleared in ~10h. Most (~96%) gone by ~2d.
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Mechanism, evidence, legal path, cost — all side-by-side.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
The Amazentis (Timeline Nutrition) compound. Phase 2 RCT (Andreux 2019) showed improved mitochondrial gene expression and muscle function in older adults. The Olympia supplement delivers standardized 500 mg directly — bypassing the gut microbiome conversion step that only ~30% of people can do from dietary sources.
Interesting longevity signals with mechanistic plausibility — but most human data is still in early collection. The biology is real; the human response curve isn't fully mapped yet. Users in this tier are genuinely contributing to what becomes established evidence.
Relatively new to market — most evidence is from the Amazentis-funded trial (industry funding). Long-term safety in humans not established. Premium pricing ($60–90/month) for ~3–4 months before effects are measurable.
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- CLimited evidence
Postbiotic produced when gut microbiome metabolizes ellagitannins (from pomegranate, walnuts, berries)
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Dietary supplement (novel food in EU — requires approval per country).
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