Urolithin A
Postbiotic produced when gut microbiome metabolizes ellagitannins (from pomegranate, walnuts, berries). Activates mitophagy — the selective clearance of damaged mitochondria. Timeline is weeks, not days.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
The Amazentis (Timeline Nutrition) compound. Phase 2 RCT (Andreux 2019) showed improved mitochondrial gene expression and muscle function in older adults. The Olympia supplement delivers standardized 500 mg directly — bypassing the gut microbiome conversion step that only ~30% of people can do from dietary sources.
Relatively new to market — most evidence is from the Amazentis-funded trial (industry funding). Long-term safety in humans not established. Premium pricing ($60–90/month) for ~3–4 months before effects are measurable.
Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- CLimited evidence
Urolithin A — primary mechanism: postbiotic produced when gut microbiome metabolizes ellagitannins (from pomegranate, walnuts, berries). activates mitophagy — the selective clearance of damaged mitochondria. timeline is weeks, not days.
2 supporting referencesVerified 5d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Dietary supplement (novel food in EU — requires approval per country).