VEGF (Vascular Endothelial Growth Factor)
Angiogenic glycoprotein. Drives endothelial cell proliferation + capillary network formation at wound + ischemic tissue sites. The mechanism behind 'better blood supply heals faster.'
How it clearsHalf cleared in ~30min. Most (~96%) gone by ~2.5h.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Best-known therapeutically as the TARGET of anti-VEGF drugs (bevacizumab, ranibizumab) for cancer + macular degeneration — blocking VEGF starves tumors + stops abnormal retinal vasculature. Pro-VEGF therapeutic use (driving angiogenesis at wound sites) exists in regenerative medicine but is research-grey. The cancer-promotion concern via tumor angiogenesis is the central caveat. Blueprint Serum includes VEGF — the topical formulation operates well below systemic exposure that would drive tumor risk.
Tumor-angiogenesis is the dominant safety concern. Contraindicated in any patient with active malignancy or recent cancer history. Topical formulations claim to operate locally without systemic exposure — verify formulation specifics. Theoretical concern for promoting growth of pre-clinical malignant cells via systemic angiogenic signaling.
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- DMechanistic / anecdotal
VEGF (Vascular Endothelial Growth Factor) — primary mechanism: angiogenic glycoprotein. drives endothelial cell proliferation + capillary network formation at wound + ischemic tissue sites. the mechanism behind 'better blood supply heals faster.'
2 supporting referencesVerified 13d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Anti-VEGF drugs FDA-approved · pro-VEGF therapeutic + cosmetic use is research-grey
Pre-filled with this compound's published dose range: Topical: ppm-level in serum formulations · twice daily, topical
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