VIP (Vasoactive Intestinal Peptide)
28-aa peptide of the secretin/glucagon family. Modulates vascular tone, anti-inflammatory cytokine balance, neuroimmune crosstalk. Central to the Shoemaker 'biotoxin / CIRS' protocol — used as nasal spray for chronic-inflammatory-response syndrome.
How it clearsHalf cleared in ~30min. Most (~96%) gone by ~2.5h.
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This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Shoemaker's CIRS (Chronic Inflammatory Response Syndrome) protocol uses VIP nasal spray as the final step after biotoxin exposure remediation. The CIRS framework is controversial in mainstream medicine — not in DSM/ICD, no large RCT validation — but has a dedicated patient + practitioner community including veterans with mold-exposure illness, post-COVID-long syndromes, Lyme co-infection cohorts. VIP has FDA-approved indications via inhaled formulation (aviptadil/Zyesami) tested in COVID-19 ARDS — emergency-use trials in 2020-21 showed mortality signal in subgroup analyses, mixed in primary endpoint.
CIRS framework is contested in mainstream medicine — Stack catalogs VIP because the cohort runs it, not as endorsement of the diagnostic framework. Practitioners require Shoemaker-protocol biotoxin remediation BEFORE VIP — using VIP without that sequencing reportedly worsens symptoms in some users. Compounding pharmacy quality varies severely on nasal VIP.
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Upload a lab file (LabCorp / Quest) or DNA file (23andMe / AncestryDNA). Stack will show your specific markers alongside the literature-reported response windows.
Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- DMechanistic / anecdotal
VIP (Vasoactive Intestinal Peptide) — primary mechanism: 28-aa peptide of the secretin/glucagon family. modulates vascular tone, anti-inflammatory cytokine balance, neuroimmune crosstalk. central to the shoemaker 'biotoxin / cirs' protocol — used as nasal spray for chronic-inflammatory-response syndrome.
2 supporting referencesVerified 13d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
503A-compounded · CIRS protocol is non-mainstream-medicine · aviptadil (inhaled VIP) was investigational for COVID-19 ARDS
Pre-filled with this compound's published dose range: 50 mcg per nostril · 4× daily, intranasal
Draw volume is below 5 units — hard to measure accurately on most syringes. Consider adding more BAC water to dilute, or moving to a smaller syringe.
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
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Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.