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Monograph
RESEARCH GREYP-013
Cognition

Selank

Synthetic analog of tuftsin. Anxiolytic without sedation; modulates GABAergic and serotonergic tone.

ExperimentalCognition
Typical dose250-750 µg
Frequencydaily, intranasal
Half-life0.3h
Citations indexed17
DeliveryInjectable
Half-life~18min
EvidenceExperimental
Citations17
Synergy checkCompareReconstitution calc
Research grey

This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.

Mechanism

Thr-Lys-Pro-Arg-Pro-Gly-Pro. Developed alongside Semax. Modulates enkephalin metabolism and GABA-A receptor function. Russian clinical trials report anxiolytic effects without sedation, dependence, or withdrawal — a profile that is unusual if it replicates. Western RCTs are absent.

Specifics
AnxietyMoodBrain fog
Caveats

All efficacy literature from one Russian institute lineage. Counterfeit risk for nasal sprays. Anxiolytic without sedation/dependence is an extraordinary claim — treat skeptically until Western replication.

sequence · 7 aa
TKPRPGP
Evidence levelExperimental
Regulatory statusCompounding nomination withdrawn Apr 2026 — distinct from peptides under PCAC review
DNA / pharmacogenomicsLow — No PG protocol.
Pairs & ConflictsCheck full stack →
Synergizes with

Mechanistically distinct — hits a different pathway.

Semax
Where the experts disagree

Stack doesn't rank peptides — we surface the diversity of opinion. Each card paraphrases a public-record stance from a named source. Where they conflict is where you should slow down and read both.

Research labRussian Academy of Sciences peptide research (Ashmarin lab lineage)

Selank is a heptapeptide derivative of tuftsin developed at the Russian Academy of Medical Sciences in the 1990s. Russian-language clinical literature documents anxiolytic effect without sedation or dependence. Western RCT replication is absent; the 'no dependence' claim for an anxiolytic is extraordinary and remains unverified outside Russian-academy lineage.

RCT / meta-analysisWestern peer-reviewed nootropic literature, 2015-2024

Outside Russian-language sources, Selank has near-zero registered clinical trials. The 'anxiolytic without GABAergic side effects' mechanism is plausible but uncorroborated by Western trials. PCAC nomination was withdrawn in April 2026 (separate procedural path from Semax).

Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • CLimited evidence

    Selank shows anxiolytic effect in Russian clinical literature, comparable in profile to medazepam without sedation

    1 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — Selank
  • ReviewRU
    REVIEWFunding undisclosedVerified 5d ago
    CyberLeninka — Russian-language Selank literature
Reconstitution calculatorSelank

Pre-filled with this compound's published dose range: 250-750 µg · daily, intranasal

Concentration2.50 mg/mL
Draw volume0.200 mL
Insulin syringe20.0 u
Doses per vial10
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

First cycle costCheapest legal from $40

How much a first cycle actually costs across the channels people use. Pick the protocol length you're considering — Stack multiplies the monthly band by cycle weeks. Same caveats apply: ranges are facts, quality varies, this is not legal advice.

Research grey$40–$110

Numbers reflect publicly-advertised price ranges, not vendor quotes. Insurance, prescription costs, and shipping aren't included. Channels marked unavailable are filtered out.

See pharmacies for this compound →
Price across channelsRange $40–$110/mo

Approximate monthly cost across the channels users actually consider — brand FDA-approved retail, US 503A compounding, Mexican pharmacies, MX farmacias magistrales, and the research-grey market. Stack lists ranges, not vendor names. Quality varies wildly across channels — see each band's note.

Research grey$40–$110/mo

Same Russian-source channel as Semax. Selank's PCAC nomination was withdrawn April 2026 — separate procedural path.

As of 2026-04
Supply chain

Public-source attribution across the production + distribution chain. Stack does not endorse vendors — this is who is in the chain, not which one is best.

Pharma brands (FDA-approved)
  • Selank(Various Russian manufacturers)

    RU

    Anxiolytic (Russian regulatory, not FDA)

    Source: Russian regulatory anxiolytic peptideVerified 5d ago
Research-grey channels
  • Peptide Partners

    Research
    3rd-party COA per batchFinnrick ✓US · CA · AU · UK

    One of the most consistently recommended vendors on r/Peptides since the Peptide Sciences shutdown (March 2026). Third-party COA published per batch. HPLC purity ≥99%.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Paradigm Peptide

    Research
    3rd-party COA per batchFinnrick ✓US · CA

    Long-established US vendor (7+ years). Broad catalog including GHRPs, GHRHs, and cognitive peptides. Third-party HPLC and mass-spec COA per batch. Active Finnrick Analytics coverage.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Orbitrex Peptides

    Research
    3rd-party COA per batchUS

    Newer vendor with fast turnaround and competitive pricing. Third-party COA on all products. Building Finnrick coverage. Frequently recommended post-Peptide Sciences shutdown.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • XL Peptides

    Research
    3rd-party COA per batchFinnrick ✓US · CA · AU

    Known for above-average catalog depth, including harder-to-find compounds (SS-31, humanin, Foxo4-DRI). Third-party HPLC published. Active Finnrick coverage.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Cosmic Nootropics

    Specialty Import
    3rd-party COA on requestUS · EU · AU · CA

    Primary EU-based importer for Russian-manufactured cognitive peptides: Semax, Selank, Cortexin, Cerebrolysin, Pinealon, Epitalon. Pharmaceutical-grade Russian-made products. COA from Russian manufacturers.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

RESEARCH GREYP-013

Compounding nomination withdrawn Apr 2026 — distinct from peptides under PCAC review

Apr 2026USRuling

Selank nomination withdrawn from PCAC docket

Selank's nomination for 503A bulks list inclusion was withdrawn before the PCAC panel scheduled it. Selank now follows a separate procedural path — likely requires fresh evidence submission.

Nov 2023USBan

FDA places peptides on Category 2 'significant safety concerns' list

FDA's Pharmacy Compounding Advisory Committee categorized a wide list of peptides as Category 2 ('significant safety concerns'), effectively banning their compounding at 503A and 503B pharmacies. Affected: BPC-157, TB-500, Epitalon, GHK-Cu, MOTS-c, DSIP, Dihexa, MK-677, Melanotan II, KPV, Semax, Selank, LL-37 and others.

Selank250-750 µg · daily, intranasal
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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