Heptapeptide derivative of ACTH(4-10). Modulates BDNF and NGF expression. Russian-developed nootropic.
Evidence is experimental. Most claims trace to limited human studies or animal models. Treat as a research direction, not a protocol.
Met-Glu-His-Phe-Pro-Gly-Pro. Developed at Russian Academy of Sciences. Animal models show BDNF/NGF upregulation, neuroprotection in ischemic stroke, and anxiolytic-cognitive enhancement. Russian clinical use includes stroke recovery and ADHD adjunct. Western evidence remains preclinical-dominant.
Western clinical replication limited. Most positive trials are Russian. Source quality varies; counterfeit risk elevated for nasal sprays imported from Eastern Europe.
Stack doesn't rank peptides — we surface the diversity of opinion. Each card paraphrases a public-record stance from a named source. Where they conflict is where you should slow down and read both.
Russian-academy heptapeptide derived from ACTH(4-10) sequence. Modulates BDNF and NGF expression. Decades of Russian clinical use for cognitive disorders, stroke recovery, and optic nerve atrophy. Western RCT replication is largely absent.
Popular for cognitive activation under demanding work (deadline focus, ADHD-adjacent use). Intranasal route is the standard. Counterfeit risk for grey-market sprays is real — community guidance is to source from established Russian-supply chains, never anonymous resellers.
Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 300-900 µg · daily, intranasal
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
How much a first cycle actually costs across the channels people use. Pick the protocol length you're considering — Stack multiplies the monthly band by cycle weeks. Same caveats apply: ranges are facts, quality varies, this is not legal advice.
Numbers reflect publicly-advertised price ranges, not vendor quotes. Insurance, prescription costs, and shipping aren't included. Channels marked unavailable are filtered out.
See pharmacies for this compound →Approximate monthly cost across the channels users actually consider — brand FDA-approved retail, US 503A compounding, Mexican pharmacies, MX farmacias magistrales, and the research-grey market. Stack lists ranges, not vendor names. Quality varies wildly across channels — see each band's note.
Russian-source intranasal sprays only legitimate channel outside Russia/post-Soviet states. Counterfeit risk elevated for non-Russian-supply imports.
As of 2026-04Public-source attribution across the production + distribution chain. Stack does not endorse vendors — this is who is in the chain, not which one is best.
Cognitive / nootropic (Russian regulatory approval, not FDA)
One of the most consistently recommended vendors on r/Peptides since the Peptide Sciences shutdown (March 2026). Third-party COA published per batch. HPLC purity ≥99%.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Long-established US vendor (7+ years). Broad catalog including GHRPs, GHRHs, and cognitive peptides. Third-party HPLC and mass-spec COA per batch. Active Finnrick Analytics coverage.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Newer vendor with fast turnaround and competitive pricing. Third-party COA on all products. Building Finnrick coverage. Frequently recommended post-Peptide Sciences shutdown.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Known for above-average catalog depth, including harder-to-find compounds (SS-31, humanin, Foxo4-DRI). Third-party HPLC published. Active Finnrick coverage.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
Primary EU-based importer for Russian-manufactured cognitive peptides: Semax, Selank, Cortexin, Cerebrolysin, Pinealon, Epitalon. Pharmaceutical-grade Russian-made products. COA from Russian manufacturers.
For laboratory use only / not for human consumption. Stack may earn affiliate commissions.
FDA Cat. 2 removed Apr 2026 — PCAC review Jul 23-24, 2026 (still prescription in Russia)
FDA's Pharmacy Compounding Advisory Committee scheduled to review the first cohort of peptides removed from Category 2 in April 2026. The 7 peptides on this docket are the highest-profile community names — BPC-157, TB-500, MOTS-c, Epitalon, DSIP, Semax, KPV.
FDA published a Federal Register notice on April 15 2026 removing 12 peptides from the Category 2 ('significant safety concerns') compounding list, paving the way for PCAC review for inclusion on the 503A bulks list. Peptides removed: BPC-157, TB-500, Epitalon, GHK-Cu (injectable), MOTS-c, DSIP, Dihexa Acetate, MK-677, Melanotan II, KPV, Semax, LL-37.
FDA's Pharmacy Compounding Advisory Committee categorized a wide list of peptides as Category 2 ('significant safety concerns'), effectively banning their compounding at 503A and 503B pharmacies. Affected: BPC-157, TB-500, Epitalon, GHK-Cu, MOTS-c, DSIP, Dihexa, MK-677, Melanotan II, KPV, Semax, Selank, LL-37 and others.
Semax was registered by the Russian Ministry of Health in 1994 for cognitive disorders, stroke recovery, and (separately) optic nerve atrophy. Used in Russian medicine and police/military for over 30 years.