Gonadorelin
Monograph · BGonadorelin
Synthetic GnRH (1-10). Stimulates pituitary LH and FSH release. Used clinically in fertility and TRT-axis maintenance.
How it clearsHalf cleared in ~6min. Most (~96%) gone by ~30min.
Originally FDA-approved as Factrel for diagnostic/fertility use (withdrawn from US market 2019 for commercial reasons). Now produced via 503A compounding, increasingly common in TRT clinics as an HCG alternative for testicular volume preservation. Pulsatile dosing matches endogenous GnRH; sustained dosing causes receptor desensitization (the basis of GnRH-agonist cancer therapy).
Documented hormonal pathway with strong mechanistic support. Response is not uniform — users with significant baseline deficiency feel signal earlier and more clearly than those near the normal range. If response feels subtle, that is often a baseline reading, not a compound failure.
Pulsatile dosing only — sustained dosing produces opposite effect. Compounded gonadorelin quality varies; verify pharmacy accreditation.
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- BModerate evidence
Synthetic GnRH (1-10)
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 100-300 µg · 2-3x weekly, subcutaneous
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