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Monograph
FDA APPROVEDP-031
Hormones

HCG

Human chorionic gonadotropin. LH-mimetic — stimulates testicular Leydig cells to produce testosterone. Used clinically in fertility and TRT-axis preservation.

EstablishedHormones
Typical dose250-500 IU
Frequency2-3x weekly, subcutaneous
Half-life36h
Citations indexed168
DeliveryInjectable
Half-life~2d
EvidenceEstablished
Citations168
Synergy checkCompareReconstitution calc
Mechanism

FDA-approved as Pregnyl, Novarel, Ovidrel for fertility and pediatric cryptorchidism. Off-label use during testosterone replacement therapy to maintain testicular size and intratesticular testosterone (fertility preservation). Compounded versions are common; brand products are expensive.

Specifics
Libido / sexual functionLow energy / fatigue
Caveats

Compounded HCG quality varies; verify pharmacy. False positives on home pregnancy tests are real. TRT-axis use should be supervised by a physician with bloodwork.

Evidence levelEstablished
Regulatory statusFDA approved (multiple brands)
DNA / pharmacogenomicsLow — LHCGR variants relevant for fertility response; not consumer-actionable.
Pairs & ConflictsCheck full stack →
Redundant with

Same mechanism class — adds cost without adding signal.

KisspeptinGonadorelin
Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • BModerate evidence

    HCG — primary mechanism: human chorionic gonadotropin. lh-mimetic — stimulates testicular leydig cells to produce testosterone. used clinically in fertility and trt-axis preservation.

    1 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — HCG TRT axis
Reconstitution calculatorHCG

Pre-filled with this compound's published dose range: 250-500 IU · 2-3x weekly, subcutaneous

Concentration2.50 mg/mL
Draw volume0.100 mL
Insulin syringe10.0 u
Doses per vial20
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

FDA APPROVEDP-031

FDA approved (multiple brands)

HCG250-500 IU · 2-3x weekly, subcutaneous
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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