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Monograph
PENDING · FEB 2027P-032
Hormones

Kisspeptin-10

10-amino acid C-terminal fragment of KISS1 gene product. Master regulator upstream of GnRH — stimulates LH/FSH release with high physiological precision.

EmergingHormones
Typical doseresearch-only
Frequencyresearch-protocol IV pulses
Half-life0.5h
Citations indexed89
DeliveryInjectable
Half-life~30min
EvidenceEmerging
Citations89
Similar compounds
Synergy checkCompareReconstitution calc
Mechanism

Imperial College London (Dhillo lab) clinical research uses kisspeptin in hypothalamic amenorrhea and IVF cycle optimization. Pulsatile delivery mimics endogenous GnRH biology better than HCG. Not commercialized; clinical access is research-protocol-only.

Specifics
Libido / sexual function
Caveats

Not commercially available. Anything sold as 'kisspeptin' to retail biohackers should be treated with extreme skepticism. Real protocols use IV pulse infusions, not subcutaneous self-administration.

sequence · 10 aa
YNWNSFGLRF
Evidence levelEmerging
Regulatory statusExpected reclassification — PCAC review Feb 2027
DNA / pharmacogenomicsLow — KISS1R variants underlie some hypogonadotropic hypogonadism cases.
Pairs & ConflictsCheck full stack →
Redundant with

Same mechanism class — adds cost without adding signal.

HCGGonadorelin
Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • CLimited evidence

    Kisspeptin-10 — primary mechanism: 10-amino acid c-terminal fragment of kiss1 gene product. master regulator upstream of gnrh — stimulates lh/fsh release with high physiological precision.

    1 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — Kisspeptin clinical
Reconstitution calculatorKisspeptin

Pre-filled with this compound's published dose range: research-only · research-protocol IV pulses

Concentration2.50 mg/mL
Draw volume0.100 mL
Insulin syringe10.0 u
Doses per vial20
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

PENDING · FEB 2027P-032

Expected reclassification — PCAC review Feb 2027

Feb 15, 2027USScheduled reviewUpcoming

PCAC review · February 2027 panel

FDA's Pharmacy Compounding Advisory Committee scheduled to review the second cohort of peptides removed from Category 2 in April 2026. Panel votes whether to add each to the official 503A bulks list.

Kisspeptinresearch-only · research-protocol IV pulses
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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