NMN
Monograph · BDirect NAD+ precursor. Restores cellular NAD+ pools that decline with age. Note: nucleotide, not a peptide.
How it clearsHalf cleared in ~30min. Most (~96%) gone by ~2.5h.
This compound sits in research-grey territory. The caveats below carry more weight than for FDA-approved entries — read them.
Direct precursor to NAD+ via the salvage pathway. Sinclair lab and Imai lab work motivates the longevity claim. Human RCTs (e.g., Yoshino 2021, Yamaguchi 2024) show modest insulin-sensitivity and biomarker effects; lifespan extrapolation is speculative.
Interesting longevity signals with mechanistic plausibility — but most human data is still in early collection. The biology is real; the human response curve isn't fully mapped yet. Users in this tier are genuinely contributing to what becomes established evidence.
FDA's 2022 stance complicates legal supplement sale in the US. Bioavailability of oral NMN vs. its metabolite NR is debated. Quality of grey-market product varies.
Upload a lab file (LabCorp / Quest) or DNA file (23andMe / AncestryDNA). Stack will show your specific markers alongside the literature-reported response windows.
Upload in /historyStack doesn't rank peptides — we surface the diversity of opinion. Each card paraphrases a public-record stance from a named source. Where they conflict is where you should slow down and read both.
Major proponent of NMN as NAD+ precursor for healthspan extension. Lab-published mouse data shows improved mitochondrial function and exercise capacity. Sinclair has been outspoken about personal use; controversial within the broader longevity research community.
Skeptical of oral NMN as the right NAD+ precursor — argues nicotinamide riboside (NR) and dietary niacin equivalents are better-evidenced and lower-cost. Has publicly criticized Sinclair's marketing of NMN-based products and the 'NAD+ supplement' category broadly.
Multiple short human trials (4-12 weeks) show modest blood-NAD+ elevation, walking-speed improvements, and aerobic-capacity changes. Long-term outcomes (cardiovascular, cancer-incidence, all-cause mortality) absent. Effect sizes smaller than supplement marketing suggests.
Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 500-1000 mg · daily, oral
Draw volume exceeds 100 units (1 mL). Either reduce dose or split into multiple injections.
Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.
How much a first cycle actually costs across the channels people use. Pick the protocol length you're considering — Stack multiplies the monthly band by cycle weeks. Same caveats apply: ranges are facts, quality varies, this is not legal advice.
Numbers reflect publicly-advertised price ranges, not vendor quotes. Insurance, prescription costs, and shipping aren't included. Channels marked unavailable are filtered out.
See pharmacies for this compound →Approximate monthly cost across the channels users actually consider — brand FDA-approved retail, US 503A compounding, Mexican pharmacies, MX farmacias magistrales, and the research-grey market. Stack lists ranges, not vendor names. Quality varies wildly across channels — see each band's note.
Dosing assumption: 500-1000 mg daily oral
NMN is regulatorily a supplement (not a peptide drug); sold by mainstream supplement companies. Wide quality range — third-party HPLC verification varies. FDA notice in 2022 attempted to challenge supplement classification; matter unresolved.
As of 2026-04No field reports yet
Field reports are added as users share their real-world protocols.
Next visit & citations
Running this compound? Log it in /history, then open Dr Passport before your visit. Methodology explains grades; the research dashboard sorts the full catalog with citations.