Dulaglutide
Monograph · ADulaglutide
Once-weekly GLP-1 receptor agonist fused to IgG4 Fc fragment. Eli Lilly's earlier weekly GLP-1 prior to tirzepatide.
How it clearsHalf cleared in ~5d. Most (~96%) gone by ~25d.
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FDA-approved as Trulicity. AWARD trials demonstrated A1C reduction and modest weight loss in T2D. Cardiovascular outcomes positive (REWIND). Now generally outperformed by semaglutide / tirzepatide on weight endpoints.
Cohort curves show movement — your n=1 often lags the median by one check-in cycle. The gap between "I should feel it" and "labs show it" is where most people quit early. Metabolic compounds still need lifestyle structure; modest results without it are mechanism, not failure.
Less weight-loss potency than semaglutide/tirzepatide. Same class-wide watches. Often the formulary-cheaper covered option.
Known risk or pharmacological conflict.
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Upload in /historyPer-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.
- AStrong evidence
Dulaglutide improves glycemic control and weight in AWARD trials
1 supporting referencesVerified 23d ago
External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.
Pre-filled with this compound's published dose range: 0.75-4.5 mg · weekly, subcutaneous
Draw volume exceeds 100 units (1 mL). Either reduce dose or split into multiple injections.
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